Napoleonville, LA IFUS:OTCID

On 23Jun26, IFUS offered Talking Points on the Application of SAG™, to include a connection to the creation of a “Defensive Barrier” against Fly Populations (to include the NWS Fly). The application of SAG™ as a NWS Fly Solution was driven by Ranchers successfully applying SGP+™ to their respective herds resulting in the elimination of general fly populations both on the cattle and the manure pats, as illustrated by one of many pictures captured by these ranchers and validated by visits from a DVM and Animal Scientist from SUAREC:

Furthermore, consistent reports of the elimination of normal pasture odors being replaced by spicy, woodsy scents offer additional qualitative evidence in support of the plausible application of SGP+™ and SAG™ to mitigate and possible ameliorate the NWS Fly problem in the U.S. and globally.

In summary, the NWS Fly Mitigation and/or Amelioration Strategy focuses on using both the Female’s and Male’s olfactory senses against it, so as to:

Block or eliminate NWS Female attractants from the herds and the pastures containing them.
Distract the NWS Male to attractants that make if fat, lazy, lethargic with reduced sex drive and sperm motility and concentration.
Create a phytochemical presence in the hide of the herd such that (1) the odor repels the flies, (2) the flavor is distasteful to the larvae, (3) the larvae are attacked and die, (4) and/or should a larvae survive, when dropped to the ground it finds no nutritional source to develop into a mature fly.

This NWS Fly Mitigation and/or Amelioration Strategy evolves from improved

Herd Performance through the application of SGP+™ as a NPEBR™ (Natural

Phytochemical Enhanced Bovine Ration™) and SAG™ as a NPIMSE™ (Natural Phytochemical and Ionic Mineral Soil Enhancement Technology™)…both of which focus on creating a natural olfactory repellant (for the NWS Female) and natural olfactory attractant (for the NWS Males), based on scientific studies reviewed to date

Point 1: “It is suggested that the olfactory senses of a Screwworm Fly (like most flies damaging bovine herds) are as highly evolved as any insect encountered on Earth.” (Gutierrez AP, et.al., Deconstructing the eradication of new world screwworm in North America: retrospective analysis and climate warming effects. Med Vet Entomol. 2019 Jun;33(2):282-295.

Point 2: If this is true, then logic would suggest that:

If the odors (e.g., VOC’s, Putrescine, Cadaverine, etc.) that attract the NWS Female are eliminated from the herds, then why would the NWS Female be attracted to the area?
If scents (e.g., flavonoids, etc.) that attract the NWS Male are provided such that the NWS Male sits there and eats/drinks, while having its sex drive hormones decreased through the phytochemicals and phytohormones it is consuming, then would it become less likely to breed and possibly be

rendered infertile through the reduction of its sperm concentration and/or motility?

Point 3: Point 2 then begs the questions as to whether there exists an all-natural, cost-effective, eco-friendly, and safe product and/or technology that achieves this.

Pastures with cattle feeding on SGP+™ are said to have NO flies.
Pastures with cattle feeding on SGP+™ are said to develop a woodsy, spicy scent.
“The chemical in Pistacia lentiscus that repels insects is β-caryophyllene, which is the most effective component of its essential oil. This essential oil has shown high repellent activity against various insect pests, making it a potential eco-friendly alternative to chemical repellents.” (Pistacia lentiscus essential oil has repellent effect against three major insect pests of pasta, Hind Houria Bougherra, et.al., Industrial Crops and Products, Volume 63, January 2015, Pages 249-255).
Three of the main ingredients in SGP+™ and SAG™ are said to produce βcaryophyllene (as just on example)
Also, as “wound prevention, rapid wound healing reduces VOC’s and other odorants produced from wounds”. (Koyama S, et.al., “Beta-caryophyllene enhances wound healing through multiple routes.” PLoS One. 2019 Dec

16;14(12):e0216104. doi: 10.1371/journal.pone.0216104.)

Hence, one could conclude that Step 1 is achieved in creating the “Defensive Barrier” around the herd by providing modified olfactory triggers that prevent NWS Female Fly attraction.

Point 4: Cadaverine is one of the chemicals produced from wounds in the bovine hide, and creates odor(s) said to attract the NWS. We find that: “Gallic acid (GA) does reduce cadaverine levels in the body. It regulates amino acid metabolism by suppressing the synthesis of cadaverine and enhancing its degradation, which ultimately leads to a reduction in cadaverine levels.

Ref.: “The metabolic regulation mechanism of gallic acid on biogenic amines and nitrosamines in reduced-nitrite Chinese fermented sausages: A perspective of metabolomics and metagenomics,” Qin Zhou, et.al., Food

Chemistry, Volume 456, 30 October 2024, 139900

Point 5: Another odorant that attracts NWS Female Fly is said to be Putrescine. “Gallic acid has a significant effect on putrescine production. It was found that putrescine formation from agmatine diminished in the presence of gallic acid, indicating that gallic acid can inhibit putrescine synthesis. Additionally, putrescine levels rise within hours after acidification, suggesting a direct relationship between gallic acid and putrescine levels. Therefore, gallic acid may play a role in regulating putrescine production in certain contexts. (1, 2)”

Ref. (1) “Putrescine production from agmatine by Lactobacillus hilgardii:

Effect of phenolic compounds,” María R. Alberto, et.al., Food Control,

Volume 18, Issue 8, August 2007, Pages 898-903, https://doi.org/10.1016/j.foodcont.2006.05.006

Ref. (2): “Apoptosis is one of the natural biological processes of programmed and controlled destruction of own cells in the multi-cellular organism. This mechanism is needed and affects the proper development, homeostasis, and prevention of excessive, harmful multiplication of body cells. It can be induced by various stimuli and common signalling mediators [69], such as 6-hydroxydopamine or reactive oxygen species (ROS). As reported in [70], GA exhibits dose-dependent anti-apoptotic properties as it prevents the 6-hydroxydopamine-induced apoptosis (through its autooxidation) of dopaminergic cells. The cited paper also showed that the compound affects intracellular glutathione levels, ROS production, and Ca2+ influx, which independently indicates a protective effect of GA against apoptosis.” A Concise Profile of Gallic Acid—From Its Natural Sources through Biological Properties and Chemical Methods of Determination, Dorota Wianowska, et.al., Molecules. 2023 Jan 25;28(3):1186.

Point 6: Chios Mastic Gum. Carob, and Degraded and Depolymerized Lignin from Sugarcane Bagasse all possess Gallic Acid…along with a myriad of beneficial phytochemicals and phytohormones.

Point 7: Additionally, should a NWS Female lay in an egg, might SGP+™ and SAG™ prevent the NWS larvae from becoming a mature fly?

“Gallic acid can impair the growth of insect larvae without causing significant harm to their parasitoid wasps.” (“Effect of gallic acid on the larvae of Spodoptera litura and its parasitoid Bracon hebetor,” Abhay Punia, et.al., Sci Rep. 2021 Jan 12;11:531.

Point 8: Another phytochemical said to be produced by the ingredients in SGP+™ and SAG™ is Dihydroxybenzoic acids, which “don’t actually repel insects, but rather block the receptors that mosquitoes, gnats, punkies, no-see-ums and other insects use to detect appropriate hosts for them to bite. Blocking those receptors stops the insects from biting, so a more accurate term might be ‘bite-preventing substances.’ By the way, they can also repel some insect relatives such as ticks.” (Resource000963_Rep1073.pdf).

Point 9: Now overlay, “Screwworm females are attracted to wounds that may be as small as those caused by the feeding of the invasive cattle tick Rhipicephalus (Boophilus) microplus” (World Organisation for Animal Health, 2013), which has periodic outbreaks in Mexico and south Texas (Pérez de León et al., 2012). This may be another basis of a “Defensive Shield” of sorts.

Point 10: SAG™, which is SGP+™ aged through an IFUS Proprietary Process, has also been noted to repel flies when applied as a mulch. Decomposing watermelon typically is a huge fly attractant. However, when the melons have been allowed to decompose on mulched SAG™, no flies are present. This has been repeated for any number of decomposing fruits.

Conclusion: Our Ranchers hold that a Multi-Tiered, Interrelated Strategy applying SGP+™ and SAG™ creates a Defensive Shield around beef and dairy herds (so as to the Mitigate and/or Ameliorate impacts from the NWS Fly) through:

Improved Herd Health,
Increased Healing if injury Occurs,
Increased Concentrations of Beneficial Phytochemicals that o secrete odors as repellants for Females and attractants for males o exhibit anti-larvicidal properties, o improve hide, meat, and milk quality,

o decrease levels of VOC’s or other NWS odor attractants,

Utilizing a biomass material, so as to formulate both SGP+™ and SAG™.

“Where efforts are being expended to invent some solution to the NWS Fly infestation, the ranchers applying SGP+™ as an NPEBR™ reported the discovery of flies disappearing on cattle and manure, normal pasture odors being replaced by scents of spicy oak, and improved Herd Performance with reduction in costs and increases in revenue. These reports drive our scientific efforts so as to understand what is happening and how every customer applying SGP+™ and now SAG™ products as technologies might achieve similar or even better results. This update is driven by valuable questions being asked by you, our stockholders and stakeholders, who gave our last Shareholder Update serious consideration. For that we are grateful as each question or comment drives our inquiry into complex science. Successful application of our IFUS Product lines remains our goal, such that we expand our IMPACT on our stakeholders in a positive manner…for soil, plant, animal, and human health through safe, cost-effective, and eco-friendly supplementation. This remains our most fundamental outcome and now includes a heavy emphasis in determining the possible efficacy of SGP+™ and SAG™ in mitigating and/or ameliorating the NWS Fly. And, in doing so, we believe that you, our shareholders, will benefit,” said Marc Walther, CEO of Impact Fusion International.

Once more, we are “Back to work!”

The information provided is for informational purposes only and is not intended as medical advice. Our products are not intended to diagnose, treat, cure, or prevent any medical condition. Always consult with a qualified healthcare professional before starting any new supplement, diet, or health regimen.

For our customers of both Intact Digest™ and Intact Endurance™ you may now send your testimonials to:

mwalther@impactfusionintl.com We can also be reached at 1-800-775-4130 seven days a week.