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Part 1: Recently Published Research on Hepatic (Liver) Function Provides Additional Plausible Evidence as to the  Efficacy of IFUS Product Lines

LETTER TO THE SHAREHOLDERS

August 4, 2025

Napoleonville, LA IFUS: OTCID

Part 1: Recently Published Research on Hepatic (Liver) Function Provides 

Plausible Evidence as to the Efficacy of IFUS Product Lines  

This shareholder update will be in three parts due to the volume of information contained in each topic area. Part 1 will focus on the plausible efficacy of NutriMastic™ on hepatic (liver) function. Parts 2 & 3 will focus on the interrelated science for SGP+™ and SupremeAG™. 

The Plausible Effects of Nutri-Mastic™ on Human Hepatic (Liver) Function can be found in numerous studies as reflected below:  

IFUS Point 1N: Efficacy of Chios Mastic Gum from Pistacia lentiscus on Liver Function. There are more detailed studies in the White Paper. However, this is but a sampling of studies to establish the point: 

IFUS Point 1N-1: The hepatoprotective effect of the boiled and non-boiled aqueous extracts of Pistacia lentiscus, Phillyrea latifolia, and Nicotiana glauca, that are alleged to be effective in the treatment of jaundice in Jordanian folk medicine, was evaluated in vivo using carbon tetrachloride (CCl4) intoxicated rats as an experimental model. Plant extracts were administrated orally at a dose of 4 ml/kg body weight, containing various amounts of solid matter. Only total serum bilirubin level was reduced by treatment with non-boiled aqueous extract of N. glauca leaves, while the boiled and non-boiled aqueous extracts of the N. glauca flowers were non effective. Bilirubin level and the activity of alkaline phosphatase (ALP) were both reduced upon treatment with boiled aqueous extract of P. latifolia without reducing the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Aqueous extract of P. lentiscus (both boiled and non-boiled) showed marked antihepatotoxic activity against CCl4 by reducing the activity of the three enzymes and the level of bilirubin. The effect of the non-boiled aqueous extract was more pronounced than that of the boiled extract. (Sana Janakat, Hela Al-Merie, Evaluation of hepatoprotective effect of Pistacia lentiscus, Phillyrea latifolia and Nicotiana glauca, Journal of Ethnopharmacology, Volume 83, Issues 1–2, 2002, Pages 135-138, ISSN 0378-8741, https://doi.org/10.1016/S0378-8741(02)00241-6.

(https://www.sciencedirect.com/science/article/pii/S0378874102002416)

IFUS Point 1N-2.a: As a note, “Hepatoprotection is the ability to protect the liver by a chemical substance via restoring the function of catalase, glutathione peroxidase, and superoxide dismutase to normal levels [1,3,5]. 

Ref.(1): Madrigal-Santillán E, Madrigal-Bujaidar E, ÁlvarezGonzález I, Sumaya-Martínez MT, Gutiérrez-Salinas J, Bautista M, 

Morales-González Á, García-Luna y González-Rubio M, AguilarFaisal JL, Morales-González JA. Review of natural products with hepatoprotective effects. World J Gastroenterol. 2014 Oct 28;20(40):14787-804. doi: 10.3748/wjg.v20.i40.14787. PMID: 25356040; PMCID: PMC4209543. 

Ref.(3): Sonal Datta, Diwakar Aggarwal, Nirmala Sehrawat, Mukesh 

Yadav, Varruchi Sharma, Ajay Sharma, Abdulrazzaq N. Zghair, 

Kuldeep Dhama, Aanchal Sharma, Vikas Kumar, Anil K. Sharma, Hailian Wang, Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives, Phytomedicine, Volume 121, 2023, 155100, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2023.155100.

(https://www.sciencedirect.com/science/article/pii/S09447113230046

09)

“Highlights: 

Abstract: Background – The liver is a well-known player in the metabolism and removal of drugs. Drug metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the acquisition of homeostasis. However, liver toxicity and cell damage are not only related to the nature and dosage of a particular drug but are also influenced by other factors such as aging, immune status, environmental contaminants, microbial metabolites, gender, obesity, and expression of individual genes Furthermore, factors such as drugs, alcohol, and environmental contaminants could induce oxidative stress, thereby impairing the regenerative potential of the liver and causing several diseases. Persons suffering from other ailments and those with comorbidities are found to be more prone to drug-induced toxicities. Moreover, drug composition and drug-drug interactions could further aggravate the risk of drug-induced hepatotoxicity. A plethora of mechanisms are responsible for initiating liver cell damage and further aggravating liver cell injury, followed by impairment of homeostasis, ultimately leading to the generation of reactive oxygen species, immune-suppression, and oxidative stress. 

Objective: To summarize the potential of phytochemicals and natural bioactive compounds to treat hepatotoxicity and other liver diseases. 

Study design: A deductive qualitative content analysis approach was employed to assess the overall outcomes of the research and review articles pertaining to hepatoprotection induced by natural drugs, along with analysis of the interventions. 

Methods: An extensive literature search of bibliographic databases, including Web of Science, PUBMED, SCOPUS, GOOGLE SCHOLAR, etc., was carried out to understand the role of hepatoprotective effects of natural drugs. 

Results: Bioactive natural products, including curcumin, resveratrol, etc., have been seen as neutralizing agents against the side effects induced by the drugs. Moreover, these natural products are dietary and are readily available; thus, could be supplemented along with drugs to reduce toxicity to cells. Probiotics, prebiotics, and symbiotics have shown promise of improving overall liver functioning, and these should be evaluated more extensively for their hepatoprotective potential. Therefore, selecting an appropriate natural product or a bioactive compound that is free of toxicity and offers a reliable solution for drug-induced liver toxicity is quintessential. 

Conclusions: The current review highlights the role of natural bioactive products in neutralizing drug-induced hepatotoxicity. Efforts have been made to delineate the possible underlying mechanism associated with the neutralization process.” 

IFUS Point 1N-2: Pandey, B., Baral, R., Kaundinnyayana, A. et al. Promising hepatoprotective agents from the natural sources: a study of scientific evidence. Egypt Liver Journal 13, 14 (2023). https://doi.org/10.1186/s43066-023-00248-w

IFUS Point 1N-2.a: “Fig. 2: Promising hepatoprotective agents from the natural sources: a study of scientific evidence: The mechanism by which herbal remedies protect against liver injury from different toxins and injurious stimuli (Al-Asmari AK, Al-Elaiwi AM, Athar MT, Tariq M, Al Eid A, Al-Asmary SM (2014) A review of hepatoprotective plants used in Saudi traditional medicine. Ev-Based 

Complement Altern Med 2014:1-22)” 

The review of studies performed on the effect of Chios Mastic Gum and other plant-based alternatives continue to show continued scientifically demonstrated efficacy against issues affecting the hepatic (liver) function of humans (as well as animals). 

“In aspiring to your company’s commitment of Research, Validation, and Commercialization of Technologies, I continue to challenge our Scientific Team to find (and where possible fund) fact-based evidence that supports or offers pathways for greater understanding of the efficacy of the IFUS Product Line. We are ever-committed to be something more than just another “snake-oil” selling supplement company. Rather, IFUS is dedicated to improving the health and wellbeing of all humans, animals, and plants being supplemented with our products. It is why as your CEO, I continue to direct our Scientific Team to explore the science being performed, and where possible to collect data, that provides fact-based evidence of the efficacy (and limits) of your company’s products,” said Marc Walther, CEO. 

Where our success record is most rewarding, IFUS does not offer “magical pills” that solve all problems. However, when applied with “Best-Practice” guidance to create an improved outcome, we are finding encouraging stories of the application of our IFUS Product Line. We are ever-dedicated to dig broader and deeper to understand the incredibly complex science behind each product. This is a daunting task at best. However, we believe this will drive our successful transition into a profitable company…one that remains committed to the purest natural products that can produce for our customers beneficial, cost-effective, and eco-friendly outcomes. 

As mentioned in a previous “Letter to the Shareholders”, “samplings” (i.e., excerpts from a series of IFUS White Papers), can be found at https://www.impactfusionbrands.com/knowledge-base/  These White Papers continue to be Works-In-Progress as more data is provided to our Team. The continued search for empirical truth reflects IFUS’s value for the improvement of human, animal, and plant health while healing the planet…all in a safe, eco-friendly, and costeffective manner. Hence, Research, Validation, and Commercialization of products that are as “All Natural” as possible remains paramount. 

Once more, this excerpt focuses on Chios Mastic Gum (a key component of NutriMastic™) and can be found in the IFUS White Paper: Chios Mastic Gum Plausible 

Scientific Evidence of the Efficacy of Nutri-Mastic™, SGP+™, and Supreme(AG)™ on Humans, Animals, and Plants (Rev.8-22Jul2025-ifus) Back to Work!

For our customers of both Intact Digest™ and Intact Endurance™ you may now send your testimonials to: 

mwalther@impactfusionintl.com   We can also be reached at 1-800-775-4130 seven days a week. 

About Impact Fusion International Inc. 

Impact Fusion International, Inc. is in the business of marketing products in the “Health and Wellness” sector of all international markets. It is the company’s mission to invent, develop and market these proprietary products worldwide for the health and well-being of humans and animals. 

The information contained in this release includes some statement that are not purely historical and that are “forward-looking statements.” Such forward-looking statements include, but are not limited to, statements regarding our and their management’s expectations, hopes, beliefs, intentions or strategies regarding the future, including our financial condition, results of operations. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipates,” “believes,” 

“continue,” “could,” “estimates,” “expects,” “intends,” “may,” “might,” “plans,” “possible,” “potential,” “predicts,” “projects,” “seeks,” “should,” “would” and similar expressions, or the negatives of such terms, may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. The forward-looking statements contained in this release are based on current expectations and beliefs concerning future developments and the potential effects on the parties and the corporate and administrative transactions. Forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements and represent our management’s beliefs and assumptions only as of the date hereof. Except as required by law, we assume no obligation to update these forward-looking statements, even if new information becomes available in the future. 

Contact:

Impact Fusion International Inc. 

204 Highway 1011 

Napoleonville LA 70390 

1-800-775-4130

Email: mwalther@impactfusionintl.com https://www.impactfusionbrands.com/brands

Updates can be found at the official Impact Fusion Twitter account @impactfusionI 

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